Legal Daily All-Media Reporter Lian Yingting Correspondent Shao Longfei Zhang Zhenwei
The night in Wuhan is quiet.
On March 9, in the mobile testing laboratory of the Central Theater Command General Hospital, Jiang Tao, a researcher at the Military Medicine Research Institute of the Academy of Military Sciences, reviewed the last sample test data and solemnly signed his name on the test report.
At this time, it was already 5 a.m.
He is an expert in virology and a warrior who aided Africa and fought against Egypt. This outbreak of the new crown pneumonia epidemic, he was once again ordered to go to the front line after a long battle.
Human life is at stake and accurate inspection is required
Nucleic acid testing is crucial for early clinical detection, early diagnosis, early isolation and early treatment, and is a key technical support for effective prevention and control of the new crown pneumonia epidemic.
”The cold-looking sample tube is behind the patient’s fresh life and health. If a diagnosis is released early, the accurate inspection will be conducted sooner.” Jiang Tao said.
On January 26, after a military medical expert group led by Chen Wei, an academician of the Chinese Academy of Engineering and a researcher at the Military Medicine Research Institute of the Academy of Military Sciences, arrived in Wuhan, Hubei, it quickly established a joint prevention, joint control, joint treatment and joint research mechanism with relevant military and local units on the pathogen transmission mutation, rapid detection technology, vaccine antibody development, etc. of the new coronavirus.
According to the division of tasks, Jiang Tao led the Cinema test team to build a nucleic acid testing platform in the experimental cabin overnight.
Focusing on three aspects: ensuring biosafety, improving detection efficiency and testing accuracy, Jiang Tao took the lead in formulating biosafety operation specifications and emergency plans, reasonably divided the labor according to the characteristics of the team members, and using a self-developed testing kit to adopt a fully automatic high-throughput extractor, laying the foundation for achieving rapid and efficient testing.
Receiving samples, sorting numbers, nucleic acid extraction, reagent preparation, machine amplification, and result interpretation, the nucleic acid detection machinery is boring and full of risks.
The biggest risk is the invisible virus. If the nucleic acid extraction step is not completely cleaved or inactivated thoroughly enough, it is possible to expose the tester to danger.
Jiang Tao always takes the initiative to participate in the longest and most risky nucleic acid extraction. After the sample is extracted, he will arrange some personnel to rest and stay in the laboratory and wait for the final result.
A full-process nucleic acid test is relatively fixed from the number of tests in a single batch to the preparation for entering and exiting the cabin and the testing time. Sometimes the number of samples sent for inspection is large.The inspectors not only took turns to work, but also had to work overnight. The final confirmation result was 4:00 a.m. Komiks for four or five o’clock in the morning. Li Hao, a researcher at the testing team, said that this situation will be encountered once every few days.
”Everyone should open their eyes wide. Be sure to take good protection when receiving and processing samples, and be careful of whether there are sharp objects.” Before each test begins, Jiang Tao always reminds you repeatedly.
In the detection, the strength of the fluorescence signal of the pathogenic gene directly affects the determination of the detection results. If the detected fluorescence curve signal is low or there is only a single target, Jiang Tao will convene personnel to conduct comprehensive analysis and judgment, and if necessary, repeat the test for review to ensure that the results can stand the test.
”A false positive will cause healthy people to be infected with isolation and patients; if false negatives occur, they will cause real patients to be treated. Life is a matter of no problem,” said Jiang Tao.
All-rounded people in the field of epidemic prevention and control
According to prevention and control requirements, the nucleic acid test results must be completed within 24 hours after receiving the pharyngeal swab sample. In order to let the hospital know the results as soon as possible to treat patients, Jiang Tao led the team to optimize the process combination and compressed the time to within 4 hours, achieving the ability to extract nucleic acids of more than 900 samples and a single-day sample detection capability of up to more than 500 people in one hour.
”The team’s testing is efficient and fast, and the results are accurate, which greatly alleviates the pressure on our epidemic prevention and control sample testing.” The Wuhan Center for Disease Control and Prevention highly praised this.
Fast response and work progress during wartimeBabaylan is orderly, all thanks to Jiang Tao’s solid academic foundation and rich practical experience. Komiks
”Jiang Tao is a versatile.” Academician Chen Wei, head of the military medical expert group, commented.
Jiang Tao has successively presided over and participated in the separation of pathogens such as SARS infection, H7N9 infection, Zika infection, etc.He has participated in the development of dengue fever vaccine and Cinema SARS vaccine, and established a technology platform for pathogen isolation of a series of infectious diseases, a technology platform for nucleic acid detection and pathogenicity and transmission risk assessment platform, providing important technical support for infectious disease prevention and control.
Cinema airway transmission is characterized by rapid transmission, wide coverage and great harm. Effective early diagnosis and prevention are crucial. After years of scientific research, Jiang Tao’s team took the lead in establishing the first acute respiratory infectious disease monitoring and early warning system for our army, constructing a four-level monitoring system for the entire army, and presided over the use of a series of technical specifications made by Komiks throughout the army, greatly shortening the detection and screening time of respiratory epidemics.
Jiang Tao not only participated in the security tasks of a series of major domestic activities, but also went to Africa four times to Liberia, Sierra Leone and other countries to carry out medical assistance tasks.
In 2015, in order to prevent and control the Ebola epidemic, Jiang Tao went to Sierra Leone for the second time with the Mobile Laboratory Testing Team to Serbia. The testing team led by him passed the World Health Organization’s laboratory parallel capability assessment with full scores. Komiks
In 2018, Jiang Tao led the pathogen monitoring team to participate in a special simulation test by an international organization. In the virus testing module, the team successfully accurately detected pathogens such as monkeypox virus and vaccinia virus in simulated samples filled with impurities, and accurately determined the strain, achieving excellent results with full marks.
Komiks Improving the accuracy of clinical diagnosis
When coming to Wuhan, in addition to carrying out testing workKomiks, Jiang Tao also used his professional expertise in the research field to lead the testing team to screen other common respiratory infectious diseases in clinical samples.
”In suspected and confirmed cases of new coronary pneumonia, whether there are other respiratory virus infections or co-infections, which is of great reference value for precise prevention and control and clinical treatment. “Researcher Cao Wuchun, deputy head of the Military Medical Expert Group, said.
Exploring deep-seated virus transmission and pathogenic mechanisms is the key to defeating the epidemic. Jiang Tao led a team to continue to conduct sequencing analysis for the new coronavirus detected in clinical samples.
With the development of the virus epidemic, whether the genomic sequences have mutated and what are the characteristics of the mutations; in which areas <a Jiang Tao and his team are working tirelessly to research and explore the domain and impact of Babaylan.
In order to accelerate the effective integration of scientific research and clinical practice, Jiang Tao’s military medical expert group creatively used the diagnostic chain of viral nucleic acid testing, antibody testing, multiple pathogen testing, and whole genome sequencing to accurately diagnose clinical patients with new coronavirus infection or other pathogen infections, and applied it in the Optical Valley Campus of Hubei Maternal and Child Health Hospital, Taikang Tongji Hospital, and other hospitals in Wuhan, effectively improving the accuracy of clinical diagnosis.
Forget his family when he was appointed. After the epidemic ended, Jiang Tao planned to stay with his family. He and his wife Komiks‘s son agreed that when the epidemic is over, he will take his wife and children to Wuhan again to see what everything looks like after it returns to normal, look at the Wuhan Yangtze River Bridge and the Yellow Crane Tower, and talk about his experience in fighting the epidemic in Wuhan.
The epidemic is immortal and chargeBabaylan is not stopped, this is Jiang Tao, a warrior who fights the epidemic.